Intracranial pressure and flow dynamics

Umeå has a long tradition of research and measurements regarding pressure and flows around the brain, as well as the measurement and analysis thereof. Researchers at MT-FoU work in close collaboration with neurologists and neurosurgeons to increase the understanding of the brain's pressure- and flow dynamics and how disorders in this relate to various disease states.

One way to assess this dynamic is through so-called infusion tests, where the pressure is measured in the fluid space that surrounds the brain and spinal cord, while fluid is supplied to the system. With the help of mathematical modelling, i.e. a number of equations that describe how the fluid system works, this measurement data can be used to assess whether the patient has a disorder in the fluid system.   

The equipment currently used clinically for this type of measurement, Likvor CELDA, is based on a prototype developed by researchers at MT-FoU 

Work is ongoing to improve and renew the analysis methods to provide better clinical information systems, especially in so-called normal pressure hydrocephalus.  

MRI technology can also be used to measure flows in the brain. This technology is non-invasive but does not provide the same information as an infusion test. Therefore, our research regards a combination of the technologies to provide a better overall picture of the system.  

In recent years, research has also developed towards mapping and understanding the interaction between pressure and flows in different fluid systems in the body, as well as how this is affected by gravity and changes in body position. Our research is closely related to the clinical environment and includes measurement technology (the conduction of measurements) as well as signal analysis and modelling (the processing of data and production of results), including CFD (Computational Fluid Dynamics)an advanced way to describe complex pressure and flow behaviours 

Anders Eklund -  

Active Researchers:  
Anders Eklund, Sara Qvarlander, Petter Holmlund.