NYHETER 2021-05-11

Study of the cerebrospinal fluid compartment around the optic nerve with changes in posture

A new publication in IOVS has shown that the cerebrospinal fluid compartment around and along the optic nerve decreases in size during head-up tilt as measured by MRI in healthy subjects. By combining MRI and mathematical modeling, the study further suggests that in the upright posture this decrease in volume may disrupt the cerebrospinal fluid flow and pressure communication between this compartment and the rest of the subarachnoid spaces.

These findings may bear relevance for disorders of the eye and optic nerve, such as normal tension glaucoma, and for increasing our understanding of the cerebrospinal fluid circulation and its local flows and pressure gradients. The project was led by Anders Eklund, professor of Biomedical Engineering at Umeå University and at CMTS Biomedical engineering R&D.



Holmlund P, Støverud K-H, Wåhlin A, et al. Posture-Dependent Collapse of the Optic Nerve Subarachnoid Space: A Combined MRI and Modeling Study. Invest Ophthalmol Vis Sci. 2021;62(4):26. doi:10.1167/iovs.62.4.26




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